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Combining three heart disease drugs into one pill is more effective, international clinical trial finds

Posting time:2023-02-02 05:58:22

Combining three heart disease drugs into one pill is more effective, international clinical trial finds

A large international clinical trial has found that combining three common heart disease drugs into one pill is significantly more effective at preventing cardiovascular events and death than taking each drug separately. The treatment being tested in the new trial, called Trinomia, uses a combination of three drugs. The concept of a combination drug has been widely used over the past few decades. It's based on the suggestion that patients tend to stick better with a single pill than trying to manage three or more different drug regimens. For example, a 2018 trial of a combination drug for high blood pressure found it was more effective at controlling blood pressure in patients than in patients prescribed the same three drugs separately. The combination drug used in Trinomiad is specific for heart disease and combines aspirin, ramipril and atorvastatin. To test its efficacy, the researchers recruited nearly 2,500 participants in seven countries. Participants had previously had a heart attack and were randomly assigned to one of four groups taking Trinomia or standard therapy for each drug separately. These participants were then followed up for 3 years. At the end of the three-year trial, the researchers found that people taking the combination pill were 33 percent less likely to die from a subsequent cardiovascular event than the standard regimen. The combination group also had a 24 percent lower risk of four different major cardiovascular events, such as non-fatal stroke or non-fatal heart attack, compared with those who took the three drugs separately. Valentin Fuster, who led the project, said: "The results of the paper published in SECURE are the first to find that a combination drug containing aspirin, ramipril and atorvastatin is significantly less effective in patients from a previous heart attack. Among those who recovered, there was a clinically relevant reduction in recurrent cardiovascular events because of better adherence to this simplified approach by taking simple combination drugs rather than taking them separately by routine."

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